Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy
Temporal lobe epilepsy (TLE) is a common form of adult epilepsy involving the limbic structures of the temporal lobe.Subiculum neurons act to provide a major output from the hippocampus and consist of a large population of endogenously bursting excitatory neurons.In TLE, subiculum neurons are largely spared, become hyperexcitable and show spontaneo