PRO-EXCITATORY ALTERATIONS IN SODIUM CHANNEL ACTIVITY FACILITATE SUBICULUM NEURON HYPEREXCITABILITY IN TEMPORAL LOBE EPILEPSY

Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy

Temporal lobe epilepsy (TLE) is a common form of adult epilepsy involving the limbic structures of the temporal lobe.Subiculum neurons act to provide a major output from the hippocampus and consist of a large population of endogenously bursting excitatory neurons.In TLE, subiculum neurons are largely spared, become hyperexcitable and show spontaneo

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The Bigger Picture: Why Oral Mucosa Heals Better Than Skin

Wound healing is an essential process to restore tissue integrity after trauma.Large skin wounds such as burns often heal with hypertrophic scarring and contractures, resulting in disfigurements and reduced joint mobility.Such adverse healing outcomes are less common in the oral mucosa, which generally heals faster compared to skin.Several studies

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Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells

Nobiletin (NOB) is a polymethoxylated flavonoid isolated from citrus fruit peel that has been shown to possess anti-tumor, antithrombotic, antifungal, anti-inflammatory and anti-atherosclerotic activities.The main purpose of this study was to explore the potential of using NOB to induce apoptosis in human bladder cancer cells and study the underlyi

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